Cryotherapy Guidelines For Treatment Of Breast Cancer

Cryotherapy guidelines for treatment of breast cancer - Interventional radiologist has opened the door for future treatment encourage the potential for nearly 200,000 women are diagnosed with breast cancer in the United States each year: image-guided, multiprobe cryotherapy.

In research first reported, researchers successfully froze breast cancer in patients who refused surgery, the women do not have to undergo surgery after treatment to ensure that tumors had been killed, note researchers at the Society Meeting to-35 Scientific Interventional Radiology Annual in Tampa, Florida.

"Cryotherapy is a minimally invasive open the door for new treatment potential for breast cancer and need to be tested more.

When used for local control and / or cure the potential cancer of the breast, it gives breast conservation is safe and effective with minimal discomfort for a group of women who refused surgery or had a local recurrence and needed additional management, "said Peter J. Littrup, MD, an interventional radiologist and director of the research imaging and image-guided therapy for the Barbara Ann Karmanos Cancer Institute in Detroit, Mich".

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Cryotherapy guidelines for treatment of breast cancer

This is the first study that reported breast cancer success of frozen without having to undergo surgery afterward to prove that it was completely treated, "he added. In a study of 13 patients, no recurrence local treatment look up to five years, no significant complications were noted and women happy with the cosmetic outcomes, noted Littrup, who is also a professor of radiology, urology and radiation oncology at Wayne State University in Detroit.

Cryotherapy is applied in accordance with the principles established freezing, and biopsy at the margin of the site of cryotherapy immediately after the procedure and at the site of cryotherapy in the follow-up showed all negative-no cancer, said Littrup.

In the United States, a woman is diagnosed with breast cancer every three minutes and one woman will die from the disease every 13 minutes. A woman has about a lifetime risk of 13 percent for breast cancer, with women 50 years and accounting older to about 80 percent of all breast cancer.

For women, as well as the thousands of men diagnosed every year, breast cancer treatment can be very effective but often require treatment options invasive such as surgery and chemotherapy.

Surgery offers the best chance for healing. Until long-term data are available, the treatment-such as the intervention as cryotherapy, ablation thermal, and laser therapy-are reserved for women who can not have-or refused-operation.

In the care of the cryotherapy studies, researchers used several needle-like cryo are evenly spaced and inserted through the skin to transmit the gas which is very cold directly to the tumor to freeze. This technique has been used for many years by surgeons in the operating room, however, in the last few years, the needles have become small enough to be used by the interventional radiologist through a little nick in the skin, without the need for surgery. The "ice-ball" created around the needle grows in size and destroys the tumor cells frozen.

The main benefit of cryotherapy is the visualization outstanding from the zone of ice therapy during the procedure, a low pain profile in an outpatient setting and excellent healing with scars that are minimal, said Littrup.

Breast imaging has advanced with the improvement of the real accurate in breast magnetic resonance imaging (MRI), allows to plan very good care of tumor size and extent in breast, as well as showing the damage zone is thoroughly covering the tumor after cryotherapy, he said.

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Cryotherapy guidelines for treatment of breast cancer

The main difference between this study and all previous use of cryotherapy breast is a confirmation of the lethal temperature sufficient when using two or more cryo, said Littrup. Prior to the study of breast cryotherapy has been "mysterious" used only cryoprobe single and suggested that tumors larger than 1.5 cm can not be treated, he explained.

"This is incongruent with more than 10 years to treat the prostate as a whole, which is approximately 5 centimeters, with more than six probes to produce a temperature that is well-defined sufficient deadly throughout the whole gland. We just translate this concept to breast cancer in to ensure that the temperature off far beyond all margins of the tumor is clearly to generate successful use of cryotherapy in women, "said Littrup. "

This emphasizes the important role of an interventional radiologist in pioneering image-guided therapy by appropriately using established treatment technology, moreover, appear that-to give a treatment dose which is sufficient, rather than relying only on the expertise of organ-specific from the doctor subspecialized other, "said Littrup.

"An interventional radiologist can better focus on the image-guidance similarities of nearly all of the treatment technology and thereby help lead the effort the treatment of cancer are fixed to the site many organs," added the co-author of "Cryotherapy for a Spectrum of Breast Cancer: US and CT-guidance. "

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Surgeons and radiation oncologists have long tried to provide at least a margin of 1-centimer of treatment surrounding all aspects of breast cancer local, and it's important to make sure the "surgical margin" which is the same lethal temperatures beyond all margins of the tumor with cryotherapy in this study, said Littrup.

"The well-es visualized by ULTRASOUND CT margin or MR is actually only the 0-line degrees Celsius, or isothermal, which is not sufficiently lethal to cancer cells, but unfortunately has been confused with the margin of the actual treatment. We make sure that the isotherm off around -30 degrees Celsius beyond all margins of the tumor, "said Littrup.

After consulting a breast MRI and thorough, the consent of the patient obtained for the institutional board approved cryotherapy review breast. On 13 sessions of cryotherapy, 25 breast cancer foci were treated in 13 patients, stages 1.

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