Gastroparesis Medications, Diagnosis and Treatment

Gastroparesis medications - Gastroparesis is a condition where the movement spontaneously (motility) of the muscles of the stomach do not run properly. Under normal circumstances, food is propelled by muscular contractions along the digestive tract.

In patients with gastroparesis, gastric motility does not work perfectly or even not work at all, thus inhibiting the process of gastric emptying.

This of course will disrupt the whole digestive process, which then resulted in impaired nutrition, blood sugar problems, and so on.
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Gastroparesis Medications

The Symptoms Of Gastroparesis
The symptoms commonly experienced by patients with gastroparesis are:
  • Pain the abdomen or solar plexus
  • Bloating.
  • The appetite is reduced.
  • Body weight decreased.
  • Very quickly feel satiety.
  • Nausea and vomiting.
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If gastroparesis is not addressed, the complications that can arise, among others:
  • Chaotic changes in blood sugar levels especially in diabetics.
  • Gastro-Oesophageal Reflux Disease (GORD), where stomach acid rises into the esophagus and cause irritation on the inner wall of the esophagus.
  • Food left in the stomach and then coagulates and solidifies. These clots can cause nausea and vomiting, as well as clogging of the stomach so that food cannot be distributed to the intestine.
  • Severe dehydration due to continuous vomiting.
  • A lack of nutrients.
Causes Of Gastroparesis
Until recently, the cause of gastroparesis is not known for certain. However, in many cases, gastroparesis is thought to occur due to damage to the nerves that control the muscles of the stomach (vagus nerve). The vagus nerve serves to regulate all the processes in the human gastrointestinal tract, including sending a signal in your stomach muscles to contract pushing food into the small intestine.

Some other conditions that can also cause gastroparesis is:
  • Complications from some type of surgery. Such as surgery to reduce weight (such as gastric banding, or gastric bypass) or partial removal of the stomach (gastrectomy).
  • Amyloidosis. A rare disease in which occurs the accumulation of abnormal proteins in the tissue or organ in the entire body.
  • Drugs, like pain reliever class of opioids and some antidepressants.
  • Scleroderma, a disease that causes hardening in some parts of the skin and sometimes there are also disturbances in the internal organs and blood vessels.
  • Parkinson's disease, where brain damage is progressive.
  • Diabetes type 1 or type 2 uncontrolled.

Gastroparesis Medications

The Diagnosis Of Gastroparesis

The procedure of the examination which can be done to diagnose gastroparesis, in which:
  • Test the hydrogen breath. The patient will be asked to drink sugar water, then noting the levels of hydrogen in the breathing as well as the time of detection of the gas at the airway of the patient.

  • Barium Meal Test. The patient will be asked to drink liquid barium, which will coat the walls of the digestive tract and clarify the picture on radiological examination. After that, do x-rays to see abnormalities in the digestive system.

  •  Endoscopy of the upper gastrointestinal. Using a small camera, to see the inside of the upper digestive tract.

  • Test of gastric emptying. After the patient swallows the food that has been spiked by the substance of the marker is radioactive, the scanner is positioned over the patient's stomach will monitor how much time it takes until the food out of the stomach. This is an examination which is very important in diagnosing gastroparese.

  •  CT and MR Enterografi. The second examination in more sensitive compared with conventional radiological examination to see the presence of inflammation or blockage in the intestines.

  • Wireless Motility Capsule. The patient will be asked to swallow electronic equipment that will record the duration of gastric emptying as well as other information such as pH, pressure, and temperature throughout the gastrointestinal tract.
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Treatment Of Gastroparesis

Step the treatment of gastroparesis begins with identifying and addressing the main cause. After that, the actions that can be done is:
  • Change the food menu. Patients are advised to consume food which is easily digestible.

  • Injection of Botulinum toxin on the valve that connects the stomach with the small intestine (pyloric sphincter), to weaken the muscles of the valve so that it can be open longer for gastric emptying.

  •  Drugs. There are two types of drugs used in gastroparesis, namely drugs to stimulate muscles of the stomach and drugs to suppress nausea and vomiting.

  • Electrical stimulation. An electric discharge through electrodes that are affixed to the wall of the stomach, with the goal of stimulating the muscle movement of the stomach. However the benefits of this therapy still need to be investigated further.

  •  Surgery. In severe cases where patients can't eat or drink, then it will be installed the hose into the small intestine to enter the food from the outside. The doctor can also install the vent hose of the stomach to reduce the pressure of the contents of the stomach.

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