PPI Medications : List of Proton Pump Inhibitors

Proton pump inhibitors or proton pump inhibitors (PPI) are a class of drugs ulcer is used to reduce stomach acid. There are at least five types of drugs included in this class namely omeprazole, lansoprazol, rabeprazol, pantoprazol and esomeprazol. What You need to know about PPI Medications ?

Omeprazole is the first drug approved to be used clinically in 1988 in Europe and the next two years approved used in the United. Omeprazole with brand Losec or Prisolec quickly match the popularity of the drug class of antagonists of H2 receptors (cimetidin, ranitidine) in overcoming the disorders related to gastric acid.
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PPI Medications

In 1996, Losec became the drugs most in demand in the world, and in the year 2004 over 800 million patients worldwide have been treated with this drug.

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How drugs work heartburn ppi ?

Drug ulcers type of PPI works by inhibiting the acid pump so that the stomach acid could not be released into the lumen of the stomach, and reduce the production of stomach acid significantly.

Drugs ulcers this serves to relieve the symptoms of acid reflux or GERD (gastroesophageal reflux disease), treat ulcers of the stomach and intestines (peptic ulcer disease disease, the wound on the mucosa of the stomach and intestines), and treat damage to the lower esophagus caused by acid reflux.

1982, Australian scientists find bacteria H. pylori which is then known as one of the triggers gastric ulcer disease. Some combination drugs containing antibiotics and a PPI has been able to eradicate H. pylori. One example is the drug combination of PPI, amoxicillin, and clarithromycin. The combination of these drugs have high effectiveness up to 80% to eradicate the H. pylori bacteria.

The use of other drugs PPI in addition to ulcers

In addition to being used to treat acid reflux, an ulcer drug types of proton pump inhibitors are also sometimes used outside of the indications written on the label of the drug, for example to:
  • treatment and prevention due to the ulcer caused the type of drugs NSAIDS.
  • in the syndrome of Zollinger-Ellison syndrome, PPI is required once the diagnosis is established and during the localization of the tumor done
  • as a maintenance therapy in GERD relapse especially in the esophagitis degree II and III
  • as a treatment in diseases of the complications of GERD is esophageal strictures, barrett's esophagus, and symptoms ekstraesophageal or chest pain non-cardiac.
Success stories omeprazole does not make the competitors stay silent. Line drug class of PPI was developed by the pharmaceutical industry different, that is lansoprazol (marketed in Europe in 1991, the United 1995), pantoprazol (market entry year Germany 1994), rabeprazol (marketed in the United 1999), esomeprazol (launched in America in 2001), and dekslansoprazol (2009).

From prazol-prazol is, whether there is a better one than the other? In the year 2003 emerged as the results of the study meta-analysis to compare the members of PPI. The result is there is no difference in meaning between the members of the PPI for treatment of GERD, PUD, eradication of H. pylori.

PPI Medications

Esomeprazol little more superior compared to omeprazole, is because esomeprazol is just using its active form, whereas omeprazole using a mixture of active and not active. Omeprazole in the form of free medicine without a prescription has never been approved in Indonesia. In many countries, omeprazole magnesium can be bought freely without having to use a doctor's prescription. However, the packaging says maximum usage is 14 days and only for the indication of heartburn (heartburn).

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Drug side effects ulcers type of PPI

Can be said PPI is an ulcer medication that is very well tolerated and safe, but as safe as-safe drug, there is unwanted effects. However, gastric acid has benefits for the body, so if its production is suppressed, this can facilitate the bacteria to thrive in whom Clostridium difficile that cause diarrhea. Some pathogens can colonize in the upper tract of the digestive and trigger pneumonia.

Long term usage of PPI can also interfere with the absorption of some nutrients such as magnesium, calcium, vitamin B12, and iron. As use often and tend to be excessive, a group of experts recently issued new rules on restrictions on the use of PPI.

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